SS-31 10MG

SS-31 is a synthetic, cell-permeable peptide designed to selectively target and inhibit the mitochondrial antioxidant defenses. Originally developed for its potential therapeutic applications in aging research, this compound has attracted significant interest within the academic and research communities for its biochemical properties. The 10mg vial of SS-31 presented here is intended for laboratory experimentation only and is provided for research purposes under strict compliance with ethical and regulatory guidelines.

Research Context

SS-31 was first synthesized in 2008 as a cyclized derivative of the naturally occurring peptide, SS-28. The compound exhibits exceptional mitochondrial targeting efficiency, allowing it to penetrate cell membranes and bind with high specificity to the mitochondrial antioxidant system. Initial investigations focused on its potential role in mitigating oxidative stress within cells, with preliminary findings suggesting protective effects against mitochondrial damage. Over the years, SS-31 has emerged as a powerful research tool for studying cellular aging mechanisms, mitochondrial health, and the biochemical pathways underlying tissue degeneration.

Research Overview

SS-31 has been extensively studied in preclinical models, including animal studies, to evaluate its effects on mitochondrial function, longevity, and organ protection. Early research highlighted its ability to enhance cellular resilience by depleting endogenous mitochondrial antioxidants, such as glutathione peroxidase 4 (GPX4), thereby creating a state of controlled oxidative stress. While some studies reported improvements in mitochondrial efficiency and reduced tissue damage, others noted potential side effects associated with mitochondrial depolarization and increased lipid peroxidation. The compound’s effects are dose-dependent and highly context-specific, making it a valuable yet nuanced research reagent.

Key Research Focus Areas

• Mitochondrial Antioxidant Depletion: Investigation of SS-31’s mechanism of action in selectively targeting mitochondrial antioxidants, including GPX4 and other thiol-based defenses, to probe its role in modulating oxidative stress responses.
• Cellular Aging and Longevity: Examination of SS-31’s impact on mitochondrial dysfunction, mitochondrial DNA integrity, and overall cellular senescence in model organisms, with implications for age-related diseases.
• Neuroprotection and Neurodegeneration: Exploration of SS-31’s potential to mitigate neurodegenerative processes, including Alzheimer’s and Parkinson’s disease, through its effects on mitochondrial and lysosomal function in neuronal cells.
• Organ Protection and Tissue Regeneration: Analysis of SS-31’s effects on liver, cardiac, and muscle tissues in response to injury or metabolic stress, particularly in relation to its role in enhancing resilience against oxidative damage.
• Drug Discovery and Toxicology: Assessment of SS-31’s safety profile in high-throughput screening models, including its interactions with other cellular pathways and potential off-target effects in experimental systems.

Important Safety and Compliance Information

SS-31 is a highly potent compound with well-documented biological activity, and its use in research environments requires careful handling and rigorous experimental controls. This product is intended exclusively for academic, institutional, or industrial research purposes and is not intended for therapeutic, diagnostic, cosmetic, or human or animal consumption. Users must adhere to all applicable local, national, and international regulations governing the possession and use of research chemicals. Adequate biosafety precautions, including proper disposal of waste and contamination control, must be implemented at all times.

For research use only. Not for human or animal consumption.